Manufacturers

Pan Pharmaceuticals Ltd

Salt Composition

Rifampicin (450mg)

Medicine Type

drugs

Introduction

In Tuberculosis (TB) Car 450mg Capsule is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It kills as well as stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Benefits

Take this medicine in the dose and duration as advised by your doctor. Car 450mg Capsule is to be taken empty stomach.

Description

Car 450mg Capsule is an antibiotic, used in the treatment of all forms of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body. It may be used alone or in combination with other medicines to fight serious infections.Car 450mg Capsule may also be given to people who are carriers (people who are infected, yet do not show any signs and symptoms of infection). It should be taken on an empty stomach, at least 30 minutes before a meal or 2 hours after a meal. It should be taken in the dose and duration as advised by the doctor. It is better to take it at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed. Stopping it early may make the infection to come back and harder to treat.Some people may develop side effects like low blood platelets, headache, dizziness, vomiting, nausea, and fever. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or will not go away.Before starting treatment with this medicine, you should tell your doctor if you are pregnant, breastfeeding or suffering from any liver, kidney or heart problems or if you are allergic to any medicine. You may be regularly monitored with blood tests for liver function tests while using this medicine.

How To Use

Take this medicine in the dose and duration as advised by your doctor. Car 450mg Capsule is to be taken empty stomach.

Safety Advise

- Alcohol : UNSAFE

It is unsafe to consume alcohol with Car 450mg Capsule. | - Pregnancy : CONSULT YOUR DOCTOR

Car 450mg Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. | - Breast feeding : SAFE IF PRESCRIBED

Car 450mg Capsule is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. | - Driving : UNSAFE

Car 450mg Capsule may cause side effects which could affect your ability to drive.You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive. | - Kidney : CAUTION

Car 450mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Car 450mg Capsule may be needed. Please consult your doctor. | - Liver : CONSULT YOUR DOCTOR

There is limited information available on the use of Car 450mg Capsule in patients with liver disease. Please consult your doctor.

If Miss

If you miss a dose of Car 450mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Packaging Detail

strip of 10 capsules

Package

Strip

Qty

10

Product Form

Capsule

Prescription Required

Prescription Required

Fact Box

Chemical Class :: Macrolactams|Habit Forming :: No|Therapeutic Class :: ANTI INFECTIVES|Action Class :: RNA polymerase inhibitors- Rifamycins

Primary Use

Tuberculosis (TB)

Storage

Store below 30°C

Use Of

Tuberculosis (TB)

Common Side Effect

Low blood platelets | Dizziness | Vomiting | Nausea | Fever | Abdominal pain | Skin rash | Hepatitis (viral infection of liver) | Headache | Chills | Paradoxical reactions | Increased aspartate aminotransferase | Increased alanine aminotransferase | Increased bilirubin in the blood

Alcoholinteraction

UNSAFE

Pregnancyinteraction

CONSULT YOUR DOCTOR

Lactationinteraction

SAFE IF PRESCRIBED

Drivinginteraction

UNSAFE

Kidneyinteraction

CAUTION

Liverinteraction

CONSULT YOUR DOCTOR

Manufacturer Address

c-181, midc waluj aurangabad mh 431136 in

Q A

Q. Is rifampin a penicillin/amoxicillin/sulfa drug?::: No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs| Q. Is rifampin bacteriostatic or bactericidal?::: Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria| Q. Is rifampin an inducer or inhibitor?::: Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body| Q. What is R-cin 600 used for?::: R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections| Q. What is R-cinex/Macox plus/R-cinex 600?::: R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid| Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?::: Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects| Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?::: No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections| Q. Does rifampin cause headaches?::: Yes. Headache is a possible side effect of rifampin| Q. Does rifampin change urine color/turn urine orange?::: Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful| Q. Does rifampin cause liver damage?::: Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

How It Works

Car 450mg Capsule is an antibiotic. It works by inactivating a bacterial enzyme (RNA-polymerase) which is required by bacteria to make essential proteins and to reproduce.

Interaction

Car 450mg Capsule & Fos-Aprepitant 125mg Tablet :

Concurrent use of Aprepitant and Rifampicin should be avoided. Blood levels of Aprepitant and effects of Aprepitant and Rifampicin are expected to be reduced. | Car 450mg Capsule & Apriset 150mg Injection :

Concurrent use of Aprepitant and Rifampicin should be avoided. Blood levels of Aprepitant and effects of Aprepitant and Rifampicin are expected to be reduced. | Car 450mg Capsule & Fosapine Injection 150mg :

Concurrent use of Aprepitant and Rifampicin should be avoided. Blood levels of Aprepitant and effects of Aprepitant and Rifampicin are expected to be reduced. | Car 450mg Capsule & Aprepit Kit :

Concurrent use of Aprepitant and Rifampicin should be avoided. Blood levels of Aprepitant and effects of Aprepitant and Rifampicin are expected to be reduced. | Car 450mg Capsule & Aprepep 125mg Capsule :

Concurrent use of Aprepitant and Rifampicin should be avoided. Blood levels of Aprepitant and effects of Aprepitant and Rifampicin are expected to be reduced. | Car 450mg Capsule & Aprecap 150mg Injection :

Concurrent use of Aprepitant and Rifampicin should be avoided. Blood levels of Aprepitant and effects of Aprepitant and Rifampicin are expected to be reduced. | Car 450mg Capsule & Atazor 200mg Capsule :

Concurrent use of Atazanavir and Rifampicin should be avoided. | Car 450mg Capsule & Atazor 300 Capsule :

Concurrent use of Atazanavir and Rifampicin should be avoided. | Car 450mg Capsule & Atavir 300mg Capsule :

Concurrent use of Atazanavir and Rifampicin should be avoided. | Car 450mg Capsule & Virataz 300mg Capsule :

Concurrent use of Atazanavir and Rifampicin should be avoided.

Marketer Details

Pan Pharmaceuticals Ltd | c-181, midc waluj aurangabad mh 431136 in

Reference

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1550-554. | Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1213-14. | Drugs.com. Rifampicin. [Accessed 01 Apr. 2019] (online) Available from: https://www.drugs.com/pregnancy/rifampin.html | Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 29 Mar. 2019] (online) Available from: https://www.scielo.br/j/jped/a/pKPFtLMX4jNH6tTtrqNwb4r/?format=pdf&lang=en