Manufacturers

Sunij Pharma Pvt Ltd

Salt Composition

Pyrazinamide (500mg)

Medicine Type

drugs

Introduction

In Tuberculosis (TB) Pyranij 500mg Tablet is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Benefits

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pyranij 500mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Description

Pyranij 500mg Tablet is an antibiotic that belongs to a class of medicines known as anti tuberculosis drugs. It is used in the treatment of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body.Pyranij 500mg Tablet is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification.If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose, as it may increase the side effects.Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver), increased liver enzymes and joint pain as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and might need dose modification.Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.

How To Use

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pyranij 500mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

Safety Advise

- Alcohol : CAUTION

Caution is advised when consuming alcohol with Pyranij 500mg Tablet. Please consult your doctor. | - Pregnancy : CONSULT YOUR DOCTOR

Pyranij 500mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. | - Breast feeding : SAFE IF PRESCRIBED

Pyranij 500mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. | - Driving : CONSULT YOUR DOCTOR

It is not known whether Pyranij 500mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. | - Kidney : CAUTION

Pyranij 500mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Pyranij 500mg Tablet may be needed. Please consult your doctor.Kidney function tests are advised before you start taking this medicine. | - Liver : CAUTION

Pyranij 500mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Pyranij 500mg Tablet may be needed. Please consult your doctor.Regular monitoring of liver function tests is advised before and after the start of the treatment.

If Miss

If you miss a dose of Pyranij 500mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Packaging Detail

strip of 10 tablets

Package

Strip

Qty

10

Product Form

Tablet

Prescription Required

Prescription Required

Fact Box

Chemical Class :: Nicotinic acid derivatives|Habit Forming :: No|Therapeutic Class :: ANTI INFECTIVES|Action Class :: Mycobacterial fatty acid synthase

Primary Use

Tuberculosis (TB)

Storage

Store below 30°C

Use Of

Tuberculosis (TB)

Common Side Effect

Jaundice | Hepatitis (viral infection of liver) | Increased liver enzymes | Joint pain

Alcoholinteraction

CAUTION

Pregnancyinteraction

CONSULT YOUR DOCTOR

Lactationinteraction

SAFE IF PRESCRIBED

Drivinginteraction

CONSULT YOUR DOCTOR

Kidneyinteraction

CAUTION

Liverinteraction

CAUTION

Manufacturer Address

T-1/B National Park, Gulbai Tekra, Ahmedabad – 380 015, (India)

Q A

Q. What is Pyranij 500mg Tablet and what is it used for?::: Pyranij 500mg Tablet is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis| Q. Is Pyranij 500mg Tablet bactericidal?::: Pyranij 500mg Tablet is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases| Q. How does Pyranij 500mg Tablet work/treat tuberculosis?::: Pyranij 500mg Tablet kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Pyranij 500mg Tablet is not known| Q. How does Pyranij 500mg Tablet cause hyperuricemia and gout?::: Following oral intake of Pyranij 500mg Tablet, it gets converted in the body to pyrazinoic acid (active chemical form of Pyranij 500mg Tablet). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

How It Works

Pyranij 500mg Tablet is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.

Interaction

Pyranij 500mg Tablet & Piloric 300mg Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Zylotis 100 Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Lopnol 300mg Tablet DT :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Zyrik 300 Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Abloric 300mg Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Apllinol 300mg Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Gurik 100mg Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Lodiric 100mg Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Lodiric-SR 250mg Capsule :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs. | Pyranij 500mg Tablet & Alnol 300mg Tablet :

Concurrent use of Allopurinol and Pyrazinamide should be avoided. Pyrazinamide should not be used if hyperuricemia (excess of uric acid in the blood) or gouty arthritis (sudden inflammation due to high levels of uric acid) occurs.

Marketer Details

Sunij Pharma Pvt Ltd | T-1/B National Park, Gulbai Tekra, Ahmedabad – 380 015, (India)

Reference

Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1554-555. | Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 827. | Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1171-72. | Drugs.com. Pyrazinamide. [Accessed 31 Mar. 2019] (online) Available from: https://www.drugs.com/pregnancy/pyrazinamide.html | Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198 [Accessed 29 Mar. 2019] (online) Available from: https://www.scielo.br/j/jped/a/pKPFtLMX4jNH6tTtrqNwb4r/?format=pdf&lang=en | Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from: https://cdscoonline.gov.in/CDSCO/Drugs