Manufacturers

Roche Products India Pvt Ltd

Salt Composition

Bevacizumab (400mg)

Medicine Type

drugs

Introduction

Benefits

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Description

Avastin 400mg Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.Avastin 400mg Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Avastin 400mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.The most common side effects of this medicine include rectal bleeding, taste change, and headache. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

How To Use

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Safety Advise

- Alcohol : CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Avastin 400mg Injection. Please consult your doctor. | - Pregnancy : CONSULT YOUR DOCTOR

Avastin 400mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. | - Breast feeding : CONSULT YOUR DOCTOR

Avastin 400mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. | - Driving : UNSAFE

Avastin 400mg Injection may cause side effects which could affect your ability to drive.Sleepiness and fainting have been reported with Avastin 400mg Injection and this may impair your ability to drive. | - Kidney : SAFE IF PRESCRIBED

Avastin 400mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Avastin 400mg Injection may not be needed in these patients. Please consult your doctor. | - Liver : SAFE IF PRESCRIBED

Avastin 400mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Avastin 400mg Injection may not be needed in these patients. Please consult your doctor.

If Miss

If you miss a dose of Avastin 400mg Injection, please consult your doctor.

Packaging Detail

vial of 16 ml Injection

Package

Vial

Qty

16 ml

Product Form

Injection

Prescription Required

Prescription Required

Fact Box

Chemical Class :: Monoclonal antibody (mAb)|Habit Forming :: No|Therapeutic Class :: ANTI NEOPLASTICS|Action Class :: Vascular endothelial growth factor (VEGF) inhibitor

Primary Use

Cancer of colon and rectum|Ovarian cancer|Cervical cancer|Kidney cancer|Brain tumor|Non-small cell lung cancer

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

Use Of

Cancer of colon and rectum|Ovarian cancer|Cervical cancer|Kidney cancer|Brain tumor|Non-small cell lung cancer

Common Side Effect

Exfoliative dermatitis | High blood pressure | Nosebleeds | Protein in urine | Decreased appetite | Electrolyte imbalance | Peripheral sensory neuropathy | Breathlessness | Thromboembolism | Wound healing complications | Ovarian failure | Decreased white blood cell count (lymphocytes) | Low blood platelets | Mucosal inflammation | Abscess | Cellulitis | Hypersensitivity | Rectovaginal fistula

Alcoholinteraction

CONSULT YOUR DOCTOR

Pregnancyinteraction

CONSULT YOUR DOCTOR

Lactationinteraction

CONSULT YOUR DOCTOR

Drivinginteraction

UNSAFE

Kidneyinteraction

SAFE IF PRESCRIBED

Liverinteraction

SAFE IF PRESCRIBED

Manufacturer Address

1503, 15th Floor, ‘The Capital’, Plot no. C-70, Behind ICICI Bank, BKC, Bandra (E) , Mumbai 400051

Q A

Q. What kinds of cancer can Avastin 400mg Injection be used for ?::: Avastin 400mg Injection is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor). | Q. How is Avastin 400mg Injection given?::: Avastin 400mg Injection is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction. | Q. How long can I take Avastin 400mg Injection for?::: You keep taking Avastin 400mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Avastin 400mg Injection. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.| Q. How Avastin 400mg Injection works differently from chemotherapy?::: Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Avastin 400mg Injection is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.| Q. Does a person taking Avastin 400mg Injection still need chemotherapy?::: Chemotherapy is still needed along with taking Avastin 400mg Injection. It makes chemotherapy work better.

How It Works

Avastin 400mg Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.

Marketer Details

Roche Products India Pvt Ltd | 1503, 15th Floor, ‘The Capital’, Plot no. C-70, Behind ICICI Bank, BKC, Bandra (E) , Mumbai 400051

Reference

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40. | Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955. | Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43. | Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011]. [Accessed 26 Mar. 2019] (online) Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/125085s225lbl.pdf | Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20]. [Accessed 18 Feb. 2020] (online) Available from: https://www.ncbi.nlm.nih.gov/books/NBK501731/